Celecoxib, marketed by Pfizer under the brand name Celebrex, is a powerful NSAID, that has a selective mechanism of action, in opposition to other NSAID medications. Unlike aspirin, ibuprofen and other non-selective NSAID (non-steroidal anti-inflammatory drugs), Celecoxib does not inhibit the COX-1 receptor, which is responsible for formation and protection of gastrointestinal mucosa, while inhibiting the COX-2 receptor, which induces the production of prostaglandins, causing inflammation.
Most NSAID class drugs are known for their devastating side effects related to gastrointestinal tract, including perforations and gastrointestinal bleeding. Celecoxib is different: it is believed to have much lesser impact on gastrointestinal tract, while effectively fighting inflammation.
Celecoxib high anti-inflammatory activity makes it very helpful in case of rheumatoid arthritis, acute pain, including painful menstruation, osteoarthritis and other inflammatory diseases. The medication is manufactured in form of capsules for oral use, such as Celebrex (Celecoxib) 100 mg, 200mg, 400 mg active substance. Most common form of the drug is Celecoxib 200 mg cap.
One other feature of the drug, making it different from its analogues is Celecoxib cost. Celebrex (Celecoxib) price in India, Pakistan, Philippines, US, UK and other countries may be as high as 200 USD per monthly supply. Fortunately, the patent on the drug has expired in 2014, and Celecoxib generic equivalent medications have become available in the United States and other countries.
While Celecoxib indication is commonly known, its contraindications are often hard to determine. Only a medical specialist can run a thorough examination to tell if this medication will work fine for a patient, taking his individual health conditions into account. List of Celecoxib contraindications includes hypersensitivity to the drug's components, particularly the sulfonamide moiety.
People with history of gastrointestinal tract diseases or cardiovascular diseases should be very careful taking Celecoxib. It's best to consult a doctor before you purchase Celebrex (Celecoxib). Overdose or sensitivity to adverse effects of the drug can be a reason for severe complications, particularly in cardiovascular system and gastrointestinal tract. Please, read the instructions carefully before taking Celecoxib.
Celecoxib dosage forms are conveniently related to recommended doses of the drug for various problems. You can order Celebrex (Celecoxib) 100 mg, 200mg, 400 mg capsules, depending on the type of disease and its severity. Celecoxib dosage for gout or rheumatoid arthritis is usually set to recommended dose of 100 mg to 200 mg twice daily. Celecoxib dosage for pain and painful menstruation implies one-time administration of 400 mg of Celebrex, eventually followed by another 200 mg intake, if the pain is too strong. The further dosage is reduced to 200 mg twice daily, while needed. The medication can be given to animals, but Celecoxib dosage for dogs is not related to this guide.
There has been a Celecoxib health Canada warning issued by the government, saying that the medication may be dangerous, potentially lethal, for patients with serious cardiovascular diseases. Truly, one of the most significant adverse effects of Celecoxib is increase of risk of cardiovascular events. They include myocardial infarction, stroke, hypertension, sodium and fluid retention. Other complications may arise in relation with gastrointestinal tract: ulceration, perforation and bleeding.
It hasn't been clear, is there a generic Celecoxib medication, until 2014, when the patent has expired and FDA has officially approved generic medications, based on Celecoxib. Now, as the generic Celecoxib is available, cost of Celebrex (Celecoxib) for sale has significantly dropped. Cost of generic Celecoxib 200 mg can be as high as $160 for 90 capsules (usually enough for 45-90 days), while brand Celebrex can cost over $220 for the same amount.
Celebrex remains one of the most expensive medications, and one of the most prescribed. Celecoxib coupon is hard to get, and it is impossible to buy Celebrex (Celecoxib) over the counter in the United States. Thus, people often ask for generic name of Celecoxib, to look for it in Celebrex (Celecoxib) no prescription online pharmacy. It significantly reduces the cost of treatment, and the convenience of overnight delivery is unquestionable.
One of the most convenient and affordable ways to obtain the medication is to order generic Celebrex (Celecoxib) online and with no prescription. While the online pharmacies do not require you to have a prescription to buy the medication, they also offer a wide choice of generic drugs that may be 30-100% cheaper than the overpriced brand ones. If you're not intended to pay for the brand name and advertising expenses of the pharmaceutical companies, you can buy cheap Celebrex (Celecoxib) online without prescription in the UK, Australia, the USA, Canada, India and many other countries.
It doesn't mean that you should use it for self-medication. Consultation with a doctor is important to determine possible risks of complications and adverse effects, related to contraindications, interactions and your individual health conditions.